I've known a couple of handgun hunters that used .44 Magnum. They practiced with .44 Special spec rounds so they wouldn't develop a flinch. With game in the sights a couple of full on magnum rounds wouldn't be a problem. I'm a wuss so I do the same with .357.
That's why I like .223, shoot it all day. My 7.62 x 54R gets old fast particularly with eastern bloc milsurp. Those guys didn't skimp on the powder. I bought some Prvi Partizan loaded ammo for the brass and worked up a little more reasonable load.