I've never seen an x86 machine that won't boot into 6.22 happily. I use a 6.22 utility disk (on 3.5 floppy) to scrub used machines before I reload them. Never played with the multiple-core unobtainium processors- mebbe that is what you are talking about. Chained under my desk at work, I have a now-considered-old Dell c640 laptop (that has fallen off the inventory records somehow), that I use to program radios. The radio service software won't run under any flavor of windows. All the hard drive has on it is 6.22 and the Motorola software. They kept trying to dispose of it on me, and I kept explaining I needed it to keep THEIR old walkie-talkies running. Finally they stopped asking about it, and on the dump from the next wall-to-wall inventory, I noticed it wasn't there any more. I'm not gonna ask questions. They can figure it out after I retire.
And I've still got stacks of beige around here, including the machine I'm typing this on, a 2ghz p4 frankenstein made up out of dumpster parts and the cheapest tower case NewEgg had 5-6 years ago.