It may make a difference - the version of Wine bundled with distros is often very out of date compared with upstream. But essentially nothing works perfectly with Wine, there are always some glitches - even little things like font/graphics issues, but usually more fundamental things. So anything working in Wine should be seen as a bonus rather than an expectation.
If you have a particular Windows program to run I'd run it in a VM - the integration between VM and host can be quick slick these days. My standard approach is to install (say) XP in a VM, turn off networking, and set up a shared folder between the VM and the host for saving your work. Don't give the VM access to all your files. Use the snapshot facility of the VM to take a known-good copy of the VM as freshly installed, and start that afresh for each session. Then you don't need to worry about updates or virus checkers.
This could be a bit awkward for a website editor tool though. You might want to have a proper networked Win7 VM instead.
Theo