It's not so much temperature differential, as the return temperature should be below 55C. If you want the radiators significantly hotter than 55C, then you'll need a high temperature differential. 70/50 is a common design criteria for a new system with a condensing boiler.
I installed a heating system and condensing boiler a few years ago. I designed it to run at 70/50 , but I have found that mostly I can run the boiler at 45C flow. This winter, it never ran at more than
55C flow. It may be that I oversized the radiators due to over- estimating the heatloss through walls, but this will have made it an even more efficent system.However, even fitting a condensing boiler into an existing system which wasn't designed for one will see efficiency gains, as the improved heat exchanger will work better even when the boiler isn't operating in condensing mode. Most of the time, max heating system output is not required, and it can fall back into condensing mode. How much of an economy it is will depend on the rest of the system, and how bad/old the existing boiler it replaces is.