Kill weeds

My garden is loaded with Senecio vulgaris (common groundsel) and Euphorbia peplus (petty spurge).

When hand-weeding, what's the best way to make sure I pull ALL of the weeds ("ROOTS AND ALL").

After weeding, what can I apply to prevent these weeds from re- emerging? (Preen Weed Preventer doesn't).

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GARY
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