Yes. Glue the joint and use course screws and the wood will break before the
joint does. Yes, I have done this. My favorite method for this kind of
construction uses biscuits with pocket screw between them. No sliding when
you screw them together and seriously strong joints. If you don't have a
biscuit joiner though, the screws alone will do the job.
I've had blow outs using MDF with the Kreg Jig and their screws. I too was
skeptical, and used some off cuts first (thankfully) and ended up going with
biscuits. Of course, perhaps it was me just tightening too much, but I did
it the same way I always used my Kreg Jig.
I worked several months in a shop manufacturing motel room furniture. We
used pocket screws with plastic dowels for alignment. Just don't
overtighten the screws or you'll either end up blowing out the pocket hole
or coming through the other side of the other panel. Glue's probably a good
idea as well.
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