I did a Google on aquarium stands, as I'm going to build one into an entertainment center for the living room. All seemed to rely on massive amounts of 2x4s.
Seems like the Soviet school of engineering to me :-).
My thought is a normal 4/4 hardwood frame for each side with a torsion box for a top to prevent sag.
Instead of the torsion box I may just put some angle irons across, mortised into the sides, and then a 3/4" hardwood plywood top.
Any comments? Is there a website that tells me how to calculate the load rating of a frame and panel side? Without needing an engineering degree?