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Experts have long sounded the alarm over myocarditis, an extremely rare complication of the vaccine that causes inflammation of the heart muscle.
Data shows about one in 125,000 children and adults under 65 who were vaccinated against the virus between 2023 and 2024 developed the condition. Among men and boys under 25 years old, however, the rate rose to one in 37,000, or 3.4 per 125,000.
In the study, researchers analyzed the blood of patients who received the vaccine and those who suffered from myocarditis after being inoculated.
They found that people who suffered from the rare side-effect had elevated levels of two immune system-linked proteins in their blood.
Subsequent experimentation in mice then showed that these proteins prompted neutrophils (a type of immune cell that is the first responder to damage) to infiltrate the heart muscle, causing damage to the tissue via inflammation.
The CDC warns that an infection with the Covid virus can also cause myocarditis, suggesting the benefits of vaccination may still outweigh the risks. About 21 per 100,000 people suffer from the complication after a Covid infection, according to a 2022 study from Italy.