I my case they needed openings to get out. Had an infestation once when I didn't address it right away. They were breeding in the walls. Basically went on a cleanliness, sealing, trapping and hunting campaign. Lasted about 2 weeks. Killed the last one with a broom as he tried to chew his way out of the new entrance door weatherstripping sweep. Into -10F weather. He had no other option. Kinda tragic on a mouse scale.