Just ran across this and wanted to share it.
From Wikipedia's article on David Byrne: In 2008, Byrne and his production team programmed the Battery Maritime Building, a 99-year-old ferry terminal in Manhattan, to play music. Essentially Byrne took the old New York City building, hooked the entire structure - pipes, heaters, pillars and all, electronically to an old pipe organ, and made a playable musical instrument of it, for a piece called "Playing the Building".
How cool is THAT?!