Normally, the Aircon which come in a box and have wheels on the bottom, the hose comes with a window screen fitting, that fills the space when a sashed window is opened and lifted upwards about six inches.
Those units are better for apartment dwellers, as you might not need permission. No heavy object to drop on the next balcony. The noise from the unit, may couple into the apartment unit below.
You can also vent a portable, through a screen door. Lift the glass internal pane up one stop, lower it onto the fitting that would normally go into a sashed window. That's how I ran a portable, as my windows are not designed for a portable, so I have to use a doorway.
Neither of these is secure, and you shut off the portable when you leave the house, and close up your venting solution.
One portable will not cool the entire house. You can put a box fan in the hallway, to circulate the air, and put the portable at the other end of the house, so you can sleep. Putting two or more portables in the house, I don't think that would be very popular. Can't manage the noise. Putting both units in the same room, you could make up a custom hose fitting for venting.
One portable will not cool an entire house. The duty cycle will be
100%, and the temperature achieved is 76F instead of 72F. There is a degree of comfort, compared to "unlimited roasting" without. A single portable in a one floor house, is about half the capacity it really needs.The only way I could do window aircon here, is in bedrooms, and that's a non-starter. I've stayed in motels with a 10,000 BTU window aircon, and that's borderline madness. You can't really get a nights sleep. It's cool though. The smaller number of square feet, and the 10000 BTU rating, means the duty cycle does not have to be 100%. It goes off occasionally.
A split may be quieter, but you still have to make some kind of holes in the walls, and that's not always practical. With a portable or a window aircon, the hole is already there.
Paul