I don't have any personal experience, but if you say so. ;-) Stacy What's-her-name London) on What Not to Wear keeps saying that if they're fit right they feel fine.
Evidence?
Hell, I take my shoes off when I'm at my desk. ...and they're walking shoes.
I think women look nice in heels but other than that have no skin in the game. Full disclosure, SWMBO doesn't wear spikes. Never has, to my knowledge (and we've been married 40 years, if that means anything ;-).