Tightening a plumbing fixture

What's the trick to tightening a male-female plumbing joint - hand-tighten then wrench for a full rotation and/or it is at the proper postion it needs to be?
Always wonder about that part of putting in valves and such for fixtures. Part of the issue for me is that hand-tightening never has it pointing in the right direction, usually other end of the valve is pointing some other useless way, so I take the wrench to it until it is pointing the right way, oftentimes having to turn it about 300 degrees or more or sometimes when turning it with a wrench it doesn't feel snug even after getting it into the right position - so go around again, usually ending up having to muscle it that last 10 or so degrees of rotation. Am I overtightening in doing that, or is there a better way to but on a valve so that it always points in the right direction after its been properly tightened down?
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