On MSN News UK (the one that opens after you've logged out from MS Outlook on your web browser) today, in an item titled "The Safest Seat on an Airplane and 10 Other Airplane Facts You?ve Always Been Curious About":
CAN A PLANE DOOR ACTUALLY OPEN MID-FLIGHT? Rest assured, it cannot. In fact, it's actually impossible. The cabin pressure simply won't let you. As askthepilot.com explains, 'At a typical cruising altitude, up to eight pounds of pressure are pushing against every square inch of the body of the aircraft. That's over
1,100 pounds against each square foot of door.'
Surely that's wrong, the cabin is pressurised wrt to the outside pressure once the plane is at cruising altitude, and plane doors open outwards. OK, it's interlocked, but it's not pressure on the outside that's holding it closed.