Some combis have a low level pressure detector and will lock out. Most do do not. If it does not you can use it on a vented system. A boiler connected directly to a heat bank is far more efficient, than heating the cylinder via coil. You will find that the makers use the same heat exchangers on the vented and system boilers/combis. It will perform better on a vented heat bank as there will always be full flow through the boilers heat exchanger. The pump on combis are mainly on the return, so always cooler water on the pump side. The pressure vessel in the combi is just ignored. If it ever leaks just cap it off.