There's something wrong with that wiring!
The functions of the actuator wires are as follows: Brown - Live to the motor. Should be live when the programmer/room stat are calling for heat Blue - Neutral to the motor Grey - Permanent live to the micro-switch Orange - Switched live. Provides feed to boiler/pump when the valve is fully open
The 4 wires from the programmer to the actuator need to fulfill the same functions. I cannot say which is which because it depends on how they are connected at the other end.
The fact that manually operating the micro-switch makes the boiler fire suggests that the two wires connected to that (brown/grey and black/orange) are ok. On that basis, the blue wire should be connected to Neutral in the programmer and the other black wire should be live when the programmer/stat are calling for heat. My hunch is that there's discontinuity in one or other of those wires.