We had problems with installation orientation when we first purchased Lights of America bulbs. Some burned out in just a few hours use upside down. We've had no problems with any other brand.
Gideon
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Trekking Tom wrote Do not install them in a wet environment ( bathroom) or installed upside down, or inside a globe. The electronic get too hot and will brun themselves out. I have them in my outdoor lights and they work great. Also through out the house.