I have a Thule ski rack as well as a Thule cargo box. Both suffer from a poorly designed attachment system which uses knurled knobs with nuts (essentially wing nuts). They have a tendency to slowly loosen from vibration. On my last trip, one of the ski rack knobs had completely unscrewed itself and fell off inside the ski rack.
On the cargo box I cut some wooden rectangles with cutouts for the knobs which I placed over the knobs so they can't unscrew. Yesterday for the ski rack I drilled two holes on each side of the four knobs and took some aluminum tent stakes and formed then into an arc that goes over the knob and through the holes to prevent the knob from turning.
What I really wanted to find was some stainless metric locking wing nuts, but those don't seem to be available anywhere in the U.S.. SAE sizes are readily available.